Spectrum of Newcastle disease virus stability in gradients of temperature and pH期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Spectrum of Newcastle disease virus stability in gradients of temperature and pH

Affiliation:	1. Unidad de Gestión Clínica, Dermatología Médico Quirúrgica y Venereología, Hospital Universitario Virgen de las Nieves, Granada, España;2. Grupo Español de Dermatología Pediátrica, Granada, España;1. FEPAGRO – Saúde Animal, Instituto de Pesquisas Veterinárias Desidério Finamor (IPVDF), Estrada do Conde 6000, Eldorado do Sul CEP 92990-000, Rio Grande do Sul, Brazil;2. Laboratório de Virologia, Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, UFRGS. Av. Sarmento Leite 500, Sala 208, Porto Alegre CEP 90050-170, Rio Grande do Sul, Brazil;3. EMBRAPA Suínos e Aves, BR 153 Km 110, Concordia CEP: 89700-000, SC, Brazil;1. Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India;2. Regional Medical Research Centre (ICMR), Northeastern Region, Dibrugarh 786001, Assam, India;1. Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen (THM), Giessen, Germany;2. Department of Immunology, University of Tuebingen, Tuebingen, Germany;3. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Giessen, Germany

Abstract:	Newcastle disease (ND) is one of the highly pathogenic viral diseases of avian species. The disease is endemic in many developing countries where agriculture serves as the primary source of national income. Newcastle disease virus (NDV) belongs to the family Paramyxoviridae and is well characterized member among the avian paramyxovirus serotypes. The failure of vaccination is one of the major causes of NDV outbreaks in field condition. The present study gives a brief picture about the biology of NDV genome and its proteins under different conditions of temperature and pH. Our results indicate that the NDV is non-infective above 42 °C and unstable above 72 °C. The study will be useful in defining an optimum storage condition for NDV without causing any deterioration in its viability.

Keywords:	Vaccine failure Temperature Virus stability Virus titration
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