Association between the IFNG +874A/T gene polymorphism and leprosy resistance: A meta-analysis |
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| Affiliation: | 1. Instituto Leônidas e Maria Deane, Fiocruz Amazônia, Manaus, Amazonas, Brazil;2. Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil;3. Universidade Nilton Lins, Manaus, Amazonas, Brazil;4. Laboratório de Imunologia, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Brazil;1. College of Chemistry, Key Lab of Environment Friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, China;2. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China;1. Diretoria de Ensino e Pesquisa, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil;2. Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil;3. Fundação de Hematologia e Hemoterapia do Amazonas, Manaus, Amazonas, Brazil;4. Instituto de Pesquisa Leônidas & Maria Deane, Fundação Oswaldo Cruz, Manaus, Amazonas, Brazil;1. Post-graduate Program in Health Sciences: Infectious Diseases and Tropical Medicine, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil;2. Department of Clinical and Toxicological Analyses, School of Pharmacy, UFMG, Brazil;3. Department of Parasitology, Institute of Biological Sciences, UFMG, Brazil;1. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan;2. Health Tourism Research Center, Graduate School of Tourism Sciences, University of the Ryukyus, Okinawa, Japan |
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| Abstract: | Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Thus, 1573 patients and 1914 controls were included and analyzed in fixed effects model. The T allele is associated with a protective effect for leprosy under the dominant model (pooled OR = 0.83, 95% CI = 0.72–0.96, p = 0.011) suggesting that carriers of the IFNG +874T allele may be protected from developing leprosy. The T allele has been suggested to correlate with high interferon-γ levels. A phenotype with high IFN-γ producing and an increased inflammatory profile may account for these findings. This meta-analysis suggests that IFNG +874T allele is associated with leprosy resistance. |
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| Keywords: | Polymorphism Leprosy Meta-analysis Genetic resistance |
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