Enhanced haloperidol-induced prolactin stimulation with chronic neuroleptic treatment in the rat |
| |
| Authors: | M R Lynch J Woo |
| |
| Affiliation: | Research Service, Veterans Administration Medical Center, Syracuse, New York 13210. |
| |
| Abstract: | Animals were treated either acutely, or chronically for 21 days, with a low dose (0.1 mg/kg) of haloperidol, then sacrificed to obtain trunk blood for radioimmunoassay of prolactin (PRL) level. PRL concentrations on day 21 of chronic treatment were greater than two-fold those produced by acute neuroleptic. Challenge with apomorphine to rats withdrawn for 48 hours revealed similar PRL reductions as a group withdrawn from chronic vehicle injections. |
| |
| Keywords: | |
|
|
