Developmental changes in the distribution of rat brain pyroglutamate aminopeptidase,a possible determinant of endogenous cyclo(His-Pro) concentrations |
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| Authors: | Chandan Prasad Masatomo Mori Woodrum Pierson John F Wilber Ruth M Ewards |
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| Institution: | (1) Department of Medicine (Section of Endocrinology), Louisiana State University Medical Center, 1542 Tulane Avenue, 70112 New Orleans, Louisiana;(2) Department of Biochemistry, Louisiana State University Medical Center, 1542 Tulane Avenue, 70112 New Orleans, Louisiana |
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| Abstract: | The distribution of cyclo(His-Pro), thyrotropin-releasing hormone (TRH) and Pyroglutamate aminopeptidase activity in adult and developing rat brains were studied. A comparison of the subcellular distribution of Pyroglutamate aminopeptidase activity in hypothalamic and cerebral cortical extracts from adult rats exhibited remarkable differences. In hypothalamus, the enzyme activity was mainly associated with the soluble fraction whereas in cortex it was predominantly associated with the particulate fractions. During postnatal development, the brain concentrations of cyclo(His-Pro) and Pyroglutamate aminopeptidase activities declined with age. These data suggest that Pyroglutamate aminopeptidase activity, but not TRH, plays an active role in determining the levels of endogenous cyclo(His-Pro) concentrations in brain. |
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