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Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700 |
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| Authors: | Rudra Sonali Yadav Ajay Raja Rao A V S Srinivas A S S V Pandya Manisha Bhateja Pragya Mathur Tarun Malhotra Sunita Rattan Ashok Salman Mohammed Mehta Anita Cliffe Ian A Das Biswajit |
| Affiliation: | aDepartment of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, R&D III, Plot No. 20, Sector-18, Udyog Vihar Industrial Area, Gurgaon, Haryana 122015, India bDepartment of Infectious Diseases, New Drug Discovery Research, Ranbaxy Laboratories Limited, R&D III, Plot No. 20, Sector-18, Udyog Vihar Industrial Area, Gurgaon, Haryana 122015, India |
| Abstract: | Several potent oxazolidinone antibacterial agents were obtained by systematic modification of the linker between the five-membered heterocycle and the piperazinyl ring of RBx 7644 (Ranbezolid, 1) and its thienyl analogue 2, leading to the identification of an expanded spectrum compound RBx 8700 (6b). |
| Keywords: | Antibacterial Oxazolidinone RBx 8700 RBx 7644 Ranbezolid Nitrothiophene Nitrofuran |
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