Quantitative approaches to the analysis of the control and regulation of microbial metabolism |
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| Authors: | Hans V. Westerhoff Wally van Heeswijk Daniel Kahn Douglas B. Kell |
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| Affiliation: | (1) Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, NL-1066 CX Amsterdam, The Netherlands;(2) E. C. Slater Institute for Biochemical Research, University of Amsterdam, Plantage Muidergracht 12, NL-1018 TV Amsterdam, The Netherlands;(3) Department of Biological Sciences, University College of Wales, SY23 3DA Aberystwyth, Dyfed, UK |
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| Abstract: | Recently, a number of novel ways of considering the control, regulation and thermodynamics of microbial physiology have been developed and applied. We here present an overview of the new concepts involved, of their limitations and of the most recent attempts to deal with those limitations. We conclude that there no longer exist reasons of principle for vagueness in discussions of the control of microbial physiology and energetics. Further, the novel conceptual methods serve to remove part of the discordance between holistic and reductionistic views of microbial physiology. |
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| Keywords: | metabolic control analysis physiology rate limitation modelling modules |
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