Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar |
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| Authors: | Win Nwet Nwet Awale Suresh Esumi Hiroyasu Tezuka Yasuhiro Kadota Shigetoshi |
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| Affiliation: | Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan. |
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| Abstract: | The CHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC(100)) against PANC-1 cells under nutrient-deprived conditions at 1 microM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay. |
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