Induction of ornithine decarboxylase by treatment of guinea pig lymphocytes with phospholipase C |
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Authors: | A Kuramoto S Otani I Matsui S Morisawa |
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Institution: | Faculty of Biology, M.V. Lomonosov Moscow State University, Moscow 117234, USSR |
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Abstract: | Treatment of guinea pig lymphocytes with Clostridium perfringens phospholipase C but not with Naja naja snake venom phospholipase A2 increased ornithine decarboxylase activity. The increase in ornithine decarboxylase activity was suppressed by actinomycin D or cycloheximide, suggesting that de novo syntheses of RNA and protein are necessary for the increase in the enzyme activity. These results suggest that the activation of phospholipase C rather than that of phospholipase A2 is responsible for induction of ornithine decarboxylase during lymphocyte transformation. |
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Keywords: | Fatty acid Lipid Egg yolk phosphatidylcholine Singlet oxygen Singlet oxygen luminescence Quenching of singlet oxygen |
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