Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse |
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| Authors: | Helen E Gruber Igor J Puzanov Michael Bennett Vinay Kumar and Brian Gordon |
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| Institution: | (1) Department of Orthopaedic Surgery, Carolinas Medical Center, Charlotte, N.C, USA;(2) Laboratory of Molecular Pathology, Department of Pathology and Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA;(3) Department of Pathology, University of Chicago, 5841 S. Maryland Ave., Room BH S-329, Chicago, IL, USA;(4) Department of Comparative Medicine, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA |
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| Abstract: | Background Although the role of the osteoclast in bone resorption is becoming better understood, much remains to be learned about osteoclastogenesis and the exact mechanism of action of anti-resorbing agents such as 17β-estradiol. This study investigated bone and morphologic osteoclast alterations following long-term estrogen administration to the B6D2F1 mouse. B6D2F1 mice aged 4-5 weeks were exposed to high levels of estrogen via implanted silastic tubing for at least 12 weeks; controls received empty tubing. Femurs of control and treated mice were assessed with radiology, quantitative histomorphometry and transmission electron microscopy. |
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