UAG readthrough in mammalian cells: Effect of upstream and downstream stop codon contexts reveal different signals |
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| Authors: | Michel Cassan Jean-Pierre Rousset |
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| Affiliation: | 1. Centre de Génétique Moléculaire, Batiment 26, Avenue de la Terrasse, Gif sur Yvette, France
2. Institut de Génétique et Microbiologie, Batiment 400, Université Paris-Sud, France
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| Abstract: | Background Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nucleotide contexts both upstream and downstream of the stop codon, can modulate readthrough, little is known about the mechanisms involved. |
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