Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes |
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| Authors: | Robertson K A Usherwood E J Nash A A |
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| Affiliation: | Department of Veterinary Pathology, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom. |
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| Abstract: | Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors. |
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