| 昆津病毒复制子——一种新型病毒载体 |
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| 引用本文： | 李世华,李晓峰,秦鄂德,秦成峰.昆津病毒复制子——一种新型病毒载体[J].生物工程学报,2011,27(2):141-146. |
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| 作者姓名： | 李世华 李晓峰 秦鄂德 秦成峰 |
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| 作者单位： | 军事医学科学院微生物流行病研究所,病原微生物生物安全国家重点实验室,北京,100071 |
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| 基金项目： | 国家“十一五”重大科技专项课题 (No. 2008ZX10004-015) 资助。 |
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| 摘 要： | 病毒复制子 (Replicon) 是指来源于病毒基因组的能够自主复制的RNA分子，保留了病毒非结构蛋白基因，而结构蛋白基因缺失或由外源基因替代。昆津病毒 (Kunjun virus) 为黄病毒科黄病毒属成员，其复制子具有表达效率高、细胞毒性低、遗传稳定等特点，在病毒基因组复制调控机制、外源蛋白表达、新型疫苗和基因治疗等领域得到了广泛应用。以下就昆津病毒复制子系统的构建、特性及应用方面的研究进展作一综述。
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| 关 键 词： | 昆津病毒，复制子，RNA病毒，病毒载体 |
| 收稿时间： | 5/5/2010 12:00:00 AM |
| 修稿时间： | 2010/7/29 0:00:00 |
Kunjin virus replicon--a novel viral vector |
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| Li Shihua,Li Xiaofeng,Qin E'de,Qin Chengfeng.Kunjin virus replicon--a novel viral vector[J].Chinese Journal of Biotechnology,2011,27(2):141-146. |
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| Authors: | Li Shihua Li Xiaofeng Qin E'de Qin Chengfeng |
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| Institution: | State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China;State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China |
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| Abstract: | Viral replicon is a kind of self-replicating viral RNA sourced from viral genome, which contains viral non-structural genes that are critical for viral genome replication with structural proteins deleted or replaced by foreign genes. Kunjin virus is a member of the Flavivirida family, Flavivirus genus, and Kunjin virus replicon is the first and the clearly defined flavivirus replicon. Kunjun virus replicon has been regarded as an excellent viral vector on account of its high expression, lower cytotoxicity and genetic stability. These unique characteristics of kunjin virus replicons make them suitable for the study of viral genome replication, recombinant proteins production, vaccine development and gene therapy. In this article, recent progress in the development, properties and applications of kunjin virus replicon system was briefly reviewed. |
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| Keywords: | Kunjin virus replicon RNA virus viral vector |
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