环境、基因组与肿瘤

肿瘤是当前危害人类健康最严重的疾病之一。从某种程度上说，它是一种遗传性疾病，然而在肿瘤发生、发展的多个阶段里，环境因素及其它非遗传性因素也起到了明显的作用。现在认为单纯遗传因素仅能解释大约5%的肿瘤的发病机制，而大部分肿瘤的发病机制归因于外界环境因素与遗传性、获得性肿瘤易感性之间的协同作用。值得注意的是，部分肿瘤易感性来自人类基因组的多样性。因此，环境、人类基因组及肿瘤三者之间有密不可分的关系。综合所有来自流行病学和实验室研究的信息，净化环境、给予高危人群特殊的保护，将会逐渐降低肿瘤的发病率。 Abstract：Cancer is one of the most serious diseases that thre aten human being today.To some degree,it is a genetic disease but environmental and other nongenetic factors clearly play a role in many stages of neoplastic pr ocess.Genetic factors by themselves are thought to explain only about 5% of all cancer.The remainder can be attributed to external,“environment” factors that act in conjunction with both genetic and acquired susceptibility.Of note,part of the susceptibility is owing to the variety of human genome.So,environment,human genome and cancer have much to do with each other.Combining all of the informat ion from epidemiology and from research works in laboratory with policy-making and clinical works,purifying the environment,giving special protection to the po pulation at high risk,the mobility of cancer may decrease gradually in the future.

Environment, Genome and Cancer

Cancer is one of the most serious diseases that thre aten human being today.To some degree,it is a genetic disease but environmental and other nongenetic factors clearly play a role in many stages of neoplastic pr ocess.Genetic factors by themselves are thought to explain only about 5% of all cancer.The remainder can be attributed to external,“environment” factors that act in conjunction with both genetic and acquired susceptibility.Of note,part of the susceptibility is owing to the variety of human genome.So,environment,human genome and cancer have much to do with each other.Combining all of the informat ion from epidemiology and from research works in laboratory with policy-making and clinical works,purifying the environment,giving special protection to the po pulation at high risk,the mobility of cancer may decrease gradually in the futur e.