Synthesis of 25-hydroxy[23,24-3H]vitamin D3 |
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| Authors: | S Yamada H K Schnoes H F DeLuca |
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| Affiliation: | Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706 USA |
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| Abstract: | A synthesis of 25-hydroxy[23,24-3H]vitamin D3 leading to a radiochemically pure product with a specific acitivity of 78 Ci/mmol is described. The structure of the product was confirmed by comparison with unlabeled material and its biological activity was established by in vitro conversion to 1α,25-dihydroxy[23,24-3H]vitamin D3 using the chick kidney 1α-hydroxylase system. |
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