Forced Desynchrony of Orcadian Rhythms of Body Temperature and Activity in Rats |
| |
Authors: | Arjen M Strijkstra Peter Meerlo Domien G M Beersma |
| |
Institution: |
a Department of Animal Behavior, Behavioral Cognitive and Neurosciences, University of Groningen, Haren, The Netherlands
b Department of Animal Physiology, Behavioral Cognitive and Neurosciences, University of Groningen, Haren, The Netherlands
c Department of Biological Psychiatry, Behavioral Cognitive and Neurosciences, University of Groningen, Haren, The Netherlands |
| |
Abstract: | The daily rhythm in body temperature is thought to be the result of the direct effects of activity and the effects of an endogenous circadian clock. Forced desynchrony (FD) is a tool used in human circadian rhythm research to disentangle endogenous and activity-related effects on daily rhythms. In the present study, we applied an FD protocol to rats. We subjected 8 rats for 5 days to a 20h forced activity cycle consisting of lOh of forced wakefulness and lOh for rest and sleep. The procedure aimed to introduce a lOh sleep/ lOh wake cycle, which period was different from the endogenous circadian (about 24h) rhythm. Of the variation in the raw body temperature data, 68-77% could be explained by a summation of estimated endogenous circadian cycle and forced activity cycle components of body temperature. Free-running circadian periods of body temperature during FD were similar to free-running periods measured in constant conditions. The applied forced activity cycle reduced clock-related circadian modulation of activity. This reduction of circadian modulation of activity did not affect body temperature. Also, the effects of the forced activity on body temperature were remarkably small. |
| |
Keywords: | SCN Sleep Suprachiasmatic nucleus Telemetry |
本文献已被 InformaWorld 等数据库收录! |
|