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Synthesis and biological properties of beta-turned Abeta(31-35) constrained analogues |
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| Authors: | Pérez de Vega M Jesús Baeza José Luis García-López M Teresa Vila-Perelló Miquel Jiménez-Castells Carmen Simón Ana María Frechilla Diana del Río Joaquin Gutiérrez-Gallego Ricardo Andreu David González-Muñiz Rosario |
| Affiliation: | Instituto de Química Médica (CSIC), Juan de la Cierva, 3, 28006 Madrid, Spain. pdevega@iqm.csic.es |
| Abstract: | A series of constrained pentapeptide analogues of the fragment Abeta(31-35) has been prepared using solid phase synthesis protocols. The results of conformational studies and surface plasmon resonance (SPR) experiments seem to indicate that the affinity of these constrained analogues for immobilized Abeta(25-35) peptide could be related to their ability to adopt a Leu34N-Ile31O beta-turn-like folded conformation. |
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