Plant cell immobilization in a dual hollow fiber bioreactor |
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Authors: | Dong Jin Kim Ho Nam Chang Jang Ryol Liu |
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Institution: | (1) Dept. of Chemical Eng. and Genetic Eng. Center, KAIST, Dongdaemun, P.O. Box 131, Seoul, Korea |
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Abstract: | Summary
Lithospermum
erythrorhizon was immobilized in a dual hollow fiber bioreactor (DHFBR) to maintain high cell density and to operate continuously. The cells grew well and its dry biomass density was 325 g/L of the void volume for the cell growth. Volumetric and specific productivities of phenolics were 221 mg/L.day and 0.68 mg/g.dry wt.day, respectively, which are 58 and 2 times of those of shake flask cultures. |
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