谷氨酸受体可逆磷酸化及其功能

谷氨酸受体(GluRs)C端区存在被多种蛋白激酶磷酸化的位点，同时又能被多种蛋白磷酸酶去磷酸化，磷酸化的结果可使Ca²⁺内流增加，增强GluRs功能；去磷酸化作用则相反.正常情况下GluRs可逆磷酸化处于一种动态平衡状态，在突触可塑性机制如长时程增强(LTP)中起重要作用，而在病理状态如缺血性脑损伤中，这种平衡失衡加重兴奋性神经元损伤.

Reversible Phosphorylation of Glutamate Receptors and Its Effects

There are phosphorylation sites within the C terminal domain of glutamate receptors(GluRs) which not only can be phosphorylated by protein kinases but can be dephosphorylated by protein phosphatases also. The effects of phosphorylation can enhance Ca²⁺ influx and improve the function of GluRs, whereas dephosphorylation do on the contrary. The reversible phosphorylation of GluRs keep balance in normal conditions which play an important role in synaptic plasticity such as LTP, but it can enhance excitatory neuronal damage in pathological events such as ischemic brain damage when the balance lose.