Hydrophobic silver nanoparticles trapped in lipid bilayers: Size distribution,bilayer phase behavior,and optical properties |
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Authors: | Geoffrey D Bothun |
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Institution: | (1) Department of Chemical Engineering, University of Rhode Island, Kingston, RI 02881, USA |
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Abstract: | Background Lipid-based dispersion of nanoparticles provides a biologically inspired route to designing therapeutic agents and a means
of reducing nanoparticle toxicity. Little is currently known on how the presence of nanoparticles influences lipid vesicle
stability and bilayer phase behavior. In this work, the formation of aqueous lipid/nanoparticle assemblies (LNAs) consisting
of hydrophobic silver-decanethiol particles (5.7 ± 1.8 nm) embedded within 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)
bilayers is demonstrated as a function of the DPPC/Ag nanoparticle (AgNP) ratio. The effect of nanoparticle loading on the
size distribution, bilayer phase behavior, and bilayer fluidity is determined. Concomitantly, the effect of bilayer incorporation
on the optical properties of the AgNPs is also examined. |
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