Bomapin is a redox-sensitive nuclear serpin that affects responsiveness of myeloid progenitor cells to growth environment |
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Authors: | Patrycja Przygodzka Björn Ramstedt Tobias Tengel Göran Larsson Malgorzata Wilczynska |
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Institution: | 1.Department of Medical Biochemistry and Biophysics,Ume? University,Sweden |
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Abstract: | Background Haematopoiesis is a process of formation of mature blood cells from hematopoietic progenitors in bone marrow. Haematopoietic
progenitors are stimulated by growth factors and cytokines to proliferate and differentiate, and they die via apoptosis when
these factors are depleted. An aberrant response to growth environment may lead to haematological disorders. Bomapin (serpinb10)
is a hematopoietic- and myeloid leukaemia-specific protease inhibitor with unknown function. |
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