Escape from X inactivation in mice and humans |
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| Authors: | Joel B Berletch Fan Yang Christine M Disteche |
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| Affiliation: | 1.Department of Pathology,University of Washington,Seattle,USA;2.Department of Medicine,University of Washington,Seattle,USA |
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| Abstract: | A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment. |
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