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Doxorubicin-induced ovarian toxicity |
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| Authors: | Irit Ben-Aharon Hadas Bar-Joseph Galia Tzarfaty Lital Kuchinsky Shulamith Rizel Salomon M Stemmer Ruth Shalgi |
| Affiliation: | (1) Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petah-Tiqva, Israel;(2) Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Israel;(3) Department of Radiology, Sheba Medical Center, Tel Hashomer, Israel |
| Abstract: | BackgroundYoung cancer patients may occasionally face infertility and premature gonadal failure. Apart from its direct effect on follicles and oocytes, chemotherapy may induce ovarian toxicity via an impact on the entire ovary. The role of doxorubicin in potential ovarian failure remains obscure. Our intention was to elucidate doxorubicin-related toxicity within ovaries. |
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