The developmental roles of the extracellular matrix: beyond structure to regulation |
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Authors: | Kwok Yeung Tsang Martin C H Cheung Danny Chan Kathryn S E Cheah |
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Institution: | (1) Department of Biochemistry and Centre for Reproduction, Development & Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China; |
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Abstract: | Cells in multicellular organisms are surrounded by a complex three-dimensional macromolecular extracellular matrix (ECM).
This matrix, traditionally thought to serve a structural function providing support and strength to cells within tissues,
is increasingly being recognized as having pleiotropic effects in development and growth. Elucidation of the role that the
ECM plays in developmental processes has been significantly advanced by studying the phenotypic and developmental consequences
of specific genetic alterations of ECM components in the mouse. These studies have revealed the enormous contribution of the
ECM to the regulation of key processes in morphogenesis and organogenesis, such as cell adhesion, proliferation, specification,
migration, survival, and differentiation. The ECM interacts with signaling molecules and morphogens thereby modulating their
activities. This review considers these advances in our understanding of the function of ECM proteins during development,
extending beyond their structural capacity, to embrace their new roles in intercellula signaling. |
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