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Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome |
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| Authors: | Paola Guglierame Rosalia Maria Pasca Edda De Rossi Silvia Buroni Patrizio Arrigo Giulia Manina Giovanna Riccardi |
| Institution: | 1. Dipartimento di Genetica e Microbiologia, Università degli Studi di Pavia, Via Ferrata 1, 27100, Pavia, Italy 2. Consiglio Nazionale delle Ricerche, Istituto per lo Studio delle Macromolecole, Via De Marini 6, 16149, Genova, Italy |
| Abstract: | BackgroundBurkholderia cenocepacia is recognized as opportunistic pathogen that can cause lung infections in cystic fibrosis patients. A hallmark of B. cenocepacia infections is the inability to eradicate the organism because of multiple intrinsic antibiotic resistance. As Resistance-Nodulation-Division (RND) efflux systems are responsible for much of the intrinsic multidrug resistance in Gram-negative bacteria, this study aims to identify RND genes in the B. cenocepacia genome and start to investigate their involvement into antimicrobial resistance. |
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