Adhesive properties of Enterobacter sakazakii to human epithelial and brain microvascular endothelial cells |
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| Authors: | Jean-Philippe Mange Roger Stephan Nicole Borel Peter Wild Kwang Sik Kim Andreas Pospischil and Angelika Lehner |
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| Institution: | (1) Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland;(2) Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland;(3) Institute for Veterinary Anatomy, Vetsuisse Faculty, University of Zurich, CH-8057 Zurich, Switzerland;(4) Pediatric Infectious Diseases, School of Medicine, John Hopkins University, 21287 Baltimore, MD, USA |
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| Abstract: | Background
Enterobacter sakazakii is an opportunistic pathogen that has been associated with sporadic cases and outbreaks causing meningitis, necrotizing enterocolitis
and sepsis especially in neonates. However, up to now little is known about the mechanisms of pathogenicity in E. sakazakii. A necessary state in the successful colonization, establishment and ultimately production of disease by microbial pathogens
is the ability to adhere to host surfaces such as mucous membranes, gastric and intestinal epithelial or endothelial tissue. |
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