SigFlux: A novel network feature to evaluate the importance of proteins in signal transduction networks |
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| Authors: | Wei Liu Dong Li Jiyang Zhang Yunping Zhu and Fuchu He |
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| Institution: | (1) College of Mechanical & Electronic Engineering and Automatization, National University of Defense Technology, Changsha, China;(2) Beijing Institute of Radiation Medicine, No.27 Taiping Road, Beijing, China;(3) Beijing Proteome Research Center, No 33 Life Science Road Changping District, Beijing, China |
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| Abstract: | Background Measuring each protein's importance in signaling networks helps to identify the crucial proteins in a cellular process, find
the fragile portion of the biology system and further assist for disease therapy. However, there are relatively few methods
to evaluate the importance of proteins in signaling networks. |
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