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Allelic constitution of the hemoglobin beta chain in wild populations of the house mouse,Mus musculus |
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| Authors: | Nobumoto Miyashita Kazuo Moriwaki Mitsuru Minezawa Hiromichi Yonekawa Francois Bonhomme Shunsuke Migita Ze-chang Yu De-yuan Lu Wang Su Cho Machmud Thohari |
| Institution: | 1. Department of Cell Genetics, National Institute of Genetics, Mishima, 411, Shizuoka-ken, Japan 2. Department of Molecular Immunology, Cancer Research Institute, Kanazawa University, 920, Kanazawa, Ishikawa-ken, Japan 4. Primate Research Institute, Kyoto University, Inuyama, 484, Aichi-ken, Japan 5. Saitama Cancer Center Research Institute, Ina-machi, Kitaadachi-gun, 362, Saitama-ken, Japan 6. Institut des Sciences de l'Evolution, USTL, 34060, Montpellier, France 7. National Vaccine and Serum Institute, Beijing, China 8. Shanghai Second Medical College, Shanghai, China 9. Institute of Agricultural Sciences, 170, Suweon, Korea 10. Tropical Agricultural Pest Biology, Staff—BIOTROP, Bogar, Indonesia |
| Abstract: | We studied the allelic frequency of the hemoglobin beta chain (Hbb) of wild mice, Mus musculus, collected from 46 localities, mostly in Asia and surrounding areas. The wild populations in the northern part of China, Korea, and the central part of Japan exhibited an almost monomorphic distribution of Hbbp. In the southern part of Asia, the frequency of Hbbp decreased and Hbbd was predominant. Although Hbbs and Hbbd are generally found in Europe, the Hbbp allele was present in Southeastern Europe (Bulgaria). In the light of these results, the Hbbp allele might have originated in mice of northern Asia. |
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