Family study of common fragile sites |
| |
Authors: | Yoshitsugu Sugio Yoshikazu Kuroki |
| |
Institution: | (1) Division of Medical Genetics, Kanagawa Children's Medical Center, 2-138-4, Mutsukawa, 232 Minamiku, Yokohama, Japan;(2) Present address: Department of Pediatrics, Ogori Daiichi Hospital, 862-3, Shimogo, Ogorichyo, 754 Yoshikigun, Yamaguchi, Japan |
| |
Abstract: | Summary The frequency of folate-sensitive common fragile sites (1p31, 1q44, 3p14, 3q26.2, 6q26, 16q23, Xp22.3) was determined in 19 healthy individuals from four families. The individuals consisted of 12 males and 7 females from 1 to 59 years of age. The frequency showed intrafamilial variation, but we were unable to demonstrate that the frequency was inherited in a Mendelian codominant fashion. In eight subjects whose chromosome 3 homologues could be distinguished by Q-band polymorphism, breakages at 3p14 occurred with equal frequencies on the homologues. Our study suggests that common fragile sites are a part of normal chromosome structure, and the frequency of their expression largely depends on environmental factors. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|