| 泛素介导的蛋白质降解与肿瘤发生 |
| |
| 引用本文： | 李艳凤,张强,朱大海. 泛素介导的蛋白质降解与肿瘤发生[J]. 遗传, 2006, 28(12): 1591-1596. DOI: 10.1360/yc-006-1591 |
| |
| 作者姓名： | 李艳凤 张强 朱大海 |
| |
| 作者单位： | (中国医学科学院基础医学研究所中国协和医科大学基础医学院, 北京 100005) |
| |
| 基金项目： | 国家重点基础研究发展计划(973计划)，国家自然科学基金 |
| |
| 摘 要： | 泛素介导的蛋白质降解途径是降解细胞内蛋白质的主要途径, 在维持细胞正常的蛋白质代谢中起着至关重要的作用。泛素介导的蛋白质降解途径的异常与许多疾病特别是肿瘤的发生密切相关。通过介绍泛素介导的蛋白质降解途径在细胞周期、DNA修复、细胞凋亡中的作用, 系统阐述了泛素介导的蛋白质降解途径与肿瘤发生的关系。
|
| 关 键 词： | 基因表达调控 泛素 蛋白质降解 细胞周期 DNA修复 |
| 文章编号： | 0253-9772(2006)12-1591-06 |
| 收稿时间： | 2006-03-24 |
| 修稿时间： | 2006-04-17 |
The Ubiquitin-Proteasome Proteolytic Pathway and Tumorigenesis |
| |
| LI Yan-Feng,ZHANG Qiang,ZHU Da-Hai. The Ubiquitin-Proteasome Proteolytic Pathway and Tumorigenesis[J]. Hereditas, 2006, 28(12): 1591-1596. DOI: 10.1360/yc-006-1591 |
| |
| Authors: | LI Yan-Feng ZHANG Qiang ZHU Da-Hai |
| |
| Affiliation: | (Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical ;Sciences & Peking Union Medical College, Beijing 10005, China) |
| |
| Abstract: | The ubiquitin-proteasome proteolytic pathway, a major pathway for protein degradation in cells, plays a critical role in the protein metabolism. So abnormality of the ubiquitin-proteasome proteolytic pathway is closely related to many diseases, especially cancer. In this paper ubiquitin-proteasome proteolytic pathways during the cel between these pathways and tumorigenesis. we reviewed the study of the significant role of the cycle, DNA repair and apoptosis, especially the relationship between these pathways and tumorigenesis. |
| |
| Keywords: | gene expression and regulation ubiquitin protein degradation cell cycle DNA repair apoptosis tumorigenesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《遗传》浏览原始摘要信息 |
|
点击此处可从《遗传》下载全文 |
