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Antimalarial properties of green tea |
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| Authors: | Sannella Anna Rosa Messori Luigi Casini Angela Francesco Vincieri Franco Bilia Anna Rita Majori Giancarlo Severini Carlo |
| Institution: | Department of Infectious, Parasitic and Immunomediated Diseases, Vector-Borne Diseases and International Health Section, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. |
| Abstract: | We show here that a crude extract of green tea as well as two of its main constituents, epigallocatechin-3-gallate (EGCG) and epicatechin gallate (ECG), strongly inhibit Plasmodium falciparum growth in vitro. Both these catechins are found to potentiate the antimalarial effects of artemisinin without interfering with the folate pathway. The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies. |
| Keywords: | Malaria Artemisinin Green tea Catechins Plasmodium falciparum |
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