Di-tert-butylhydroxylated flavonoids protect endothelial cells against oxidized LDL-induced cytotoxicity |
| |
Authors: | Furman C Lebeau J Fruchart J Bernier J Duriez P Cotelle N Teissier E |
| |
Affiliation: | Département de Recherches sur les Lipoprotéines et l'Athérosclérose, INSERM U325, Institut Pasteur et Faculté de Pharmacie, Université de Lille 2, 59000 Lille, France. |
| |
Abstract: | The protective effect of di-tert-butylhydroxylated flavonoids (chalcones and arylidenes) against minimally oxidized LDL (mO-LDL)-induced cytotoxicity was studied in cultured bovine aortic endothelial cells. Most of the tested compounds decreased aldehydes formation in medium containing mO-LDL, but their capacity to inhibit LDL oxidation in the cellular medium was not sufficient to totally reduce the cellular toxicity of mO-LDL. Most of the tested flavonoids improved the integrity of cells exposed to mO-LDL, whereas butylated hydroxytoluene was ineffective and quercetin worsened the toxicity of mO-LDL. Moreover these flavonoids induced an increase in GSH cellular levels and their protective effects might be because of their inability to reduce metal ion. Arylidene 6 substituted at position 7 by a hydroxyl group was the most potent compound. |
| |
Keywords: | Di‐tert‐butylhydroxylated Flavonoids Chalcones Arylidenes LDL Oxidation Toxicity Glutathione |
本文献已被 PubMed 等数据库收录! |