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Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS. |
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| Authors: | Y Yoshikai H Kidokoro K Kimura Y Aoki M Makino K Hiromatsu |
| Abstract: | Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells. |
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