Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia |
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Authors: | Marino M J Awad H Poisik O Wittmann M Conn P J |
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Institution: | (1) Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, U.S.A., US;(2) Department of Neuroscience, Merck Research Laboratories, Merck and Co., Inc., West Point, Pennsylvania, U.S.A., US |
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Abstract: | Summary. Our current understanding of the circuitry of the basal ganglia, and the pathophysiology of Parkinson's disease has led to
major breakthroughs in the treatment of this debilitating movement disorder. Unfortunately, there are significant problems
with the currently available pharmacological therapies that focus on dopamine replacement or dopaminergic agonists. Because
of this, much effort has been focused on developing novel targets for the treatment of Parkinson's disease. The metabotropic
glutamate receptors are a family of G-protein coupled receptors activated by glutamate. These receptors are differentially
distributed throughout the basal ganglia in a manner suggesting that they may provide novel targets for the treatment of movement
disorders. In this review we summarize anatomical and physiological data from our work and the work of other laboratories
describing the distribution and physiological roles of metabotropic glutamate receptors in the basal ganglia with emphasis
on possible therapeutic targets.
Received July 2, 2001 Accepted August, 6, 2001 Published online June 26, 2002 |
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Keywords: | : Basal ganglia Metabotropic glutamate receptors Movement disorders Parkinson's disease |
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