Polymorphism of HLA class I loci HLA-A, -B, -C, in the Mandenka population from eastern Senegal] |
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| Authors: | P Dard Y Schreiber L Excoffier A Sanchez-Mazas X Shi-Isaac A Epelbouin A Langaney M Jeannet |
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| Affiliation: | Département d'Anthropologie et d'Ecologie, Université de Genève, Suisse. |
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| Abstract: | A sample of 162 Mandenkalu from Eastern Senegal has been typed for three HLA class I loci: HLA-A, -B and -C. The Mandenka population presents a very high genetic variability with 15 alleles for locus A, 24 alleles for locus B, and at least 8 alleles for locus C. The calculated heterozygosities for the three loci A, B, and C are respectively 0.884, 0.944 and 0.829. The Mandenkalu allelic frequencies are close to that found in other sub-Saharan populations. They show, however, some peculiarities like the occurrence of the Bw 56 allele and the high frequencies of both B5 and B35. |
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