Identification of [3H] histamine binding sites on gastric mucosal cells unrelated to histamine H2-receptors |
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Authors: | S Batzri J W Harmon M D Walker |
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Affiliation: | Department of Physics, Jichi Medical School, Yakushiji, Tochigi 329-04, Japan |
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Abstract: | Acidic unfolding process of myoglobin was investigated in the presence of external ligands (azide, cyanide, fluoride and imidazole). With azide, cyanide and fluoride as ligand, myoglobin unfolds through a single exponential decay process, whereas it is not the case with imidazole. No faster decays were observed as in the case of myoglobin without external ligands. These results demonstrate the important role of iron-ligand interaction on the conformational stability of myoglobin. |
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Keywords: | To whom correspondence should be addressed. |
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