(1) Department of Pharmacy, Laboratory of Therapeutic Chemistry, Claude Bernard University of Lyon, Rockefeller Avenue 8, F-69373 Lyon Cédex 08, France
Abstract:
Summary A new and convenient method for synthesizing norstatine derivatives has been developed. The key step is the preparation of propargylic alcohols from N-Fmoc or N-Boc amino aldehydes, followed by transformation to carboxylic acids after protection of the alcohols. The N-Boc-protected derivatives are coupled to a dipeptide sequence to afford peptide mimetics (norstatines).