Influence of dietary selenium on metabolism of cadmium and mercury in reproductive tissues of rats |
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| Affiliation: | 1. NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois;2. Biochemistry Center, Heidelberg University, Heidelberg, Germany;3. Interdisciplinary Center for Scientific Computing, Heidelberg, Germany;4. Department of Biochemistry, Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois;5. Department of Biophysics, Ruhr University Bochum, Bochum, Germany;1. Medical Research Center, Department of Orthopedics, Guangdong Provincial People''s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China;2. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China;3. School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China;4. School of Materials Science and Engineering, Peking University, Beijing 100871, China;1. Natural Resources Canada, CanmetENERGY, 1 Haanel Drive, K1A 1M1 Ottawa, ON, Canada;2. Second University of Naples, Department of Architecture and Industrial Design, “Luigi Vanvitelli”, via San Lorenzo, 81031 Aversa, CE, Italy;1. Department of Biochemistry and Molecular Biology and the Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA;2. Molecular, Cell and Developmental Biology Department and Molecular Biology Institute, University of California, Los Angeles, CA, 90095, USA;1. Dept of Morphology, Federal University of Espírito Santo, Brazil;2. Dept of Physiology, Federal University of Espírito Santo, Brazil |
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| Abstract: | Dietary selenium supplementation for rats resulted in a greater deposition of 109Cd in testis, but caused decreased deposition of the isotope in seminal vesicles, epididymis and prostate gland. In contrast, dietary selenium caused increased deposition of 203Hg in seminal vesicles and prostate gland but drastically reduced the levels of this radioisotope in testis and epididymis. Selenium diverted the binding of 109Cd in cytosols in testis, seminal vesicles, epididymis and prostate gland, but had minimal effects on the binding of 203Hg in these reproductive organs. Selenium deficiency caused increased excretion of 109Cd in feces and urine, and increased excretion of 203Hg in urine of rats. The biological half-lives of the two radioisotopes in the −Se and +Se rats were calculated to be, respectively, 202 and 219 days for 109Cd, and 2 and 6 days for 203Hg. |
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