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The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation

Authors:	A Joshua Wand

Institution:	The Johnson Research Foundation and Department of Biochemistry & Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104-6059, USA

Abstract:	Download : Download high-res image (171KB) Download : Download full-size image Highlights? Fast motion interconverts states with significant conformational entropy. ? Fast internal motion can be characterized in a site resolved way using solution NMR relaxation phenomena. ? Internal protein motion can be used as a proxy for conformational entropy. ? Conformational entropy can contribute significantly to ligand binding by proteins.

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