Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients. |
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| Authors: | J J Ohisalo H L Vikman S Ranta M D Houslay G Milligan |
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| Affiliation: | Rowett Research Institute, Aberdeen, Scotland, U.K. |
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| Abstract: | The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree & Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched. |
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