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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs |
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| Authors: | Tamar Pirtskhalava Adam C. Gower Husheng Ding Nino Giorgadze Allyson K. Palmer Yuji Ikeno Gene B. Hubbard Marc Lenburg Steven P. O'Hara Nicholas F. LaRusso Jordan D. Miller Carolyn M. Roos Grace C. Verzosa Nathan K. LeBrasseur Jonathan D. Wren Joshua N. Farr Sundeep Khosla Michael B. Stout Sara J. McGowan Heike Fuhrmann‐Stroissnigg Aditi U. Gurkar Jing Zhao Debora Colangelo Akaitz Dorronsoro Yuan Yuan Ling Amira S. Barghouthy Diana C. Navarro Tokio Sano Paul D. Robbins Laura J. Niedernhofer James L. Kirkland |
| Affiliation: | 1. Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA;2. Section 3. of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA;4. Departments of Pathology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA;5. Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA;6. Department of Biochemistry and Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA;7. Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA |
| Abstract: | |
| Keywords: | dasatinib dependence receptors ephrins p21 PI3K delta plasminogen‐activated inhibitor quercetin |