FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway |
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| Authors: | Xin‐Mei Liu Hsiao Chang Chan Guo‐Lian Ding Jie Cai Yang Song Ting‐Ting Wang Dan Zhang Hui Chen Mei Kuen Yu Yan‐Ting Wu Fan Qu Ye Liu Yong‐Chao Lu Eli Y Adashi Jian‐Zhong Sheng He‐Feng Huang |
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| Institution: | 1. International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;2. Department of Pathology & Pathophysiology, School of Medicine, Zhejiang University, Zhejiang, China;3. Shanghai Jiao Tong University – The Chinese University of Hong Kong Joint Research Center for Human Reproduction and Related Diseases, Shanghai, China;4. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong;5. Key Laboratory for Regenerative Medicine (Jinan University – The Chinese University of Hong Kong), Ministry of Education, Hangzhou, China;6. The Key Laboratory of Reproductive Genetics, Ministry of Education, Hangzhou, China;7. Ningbo Maternal and Child Health Hospital, Zhejiang, China;8. The Warren Alpert Medical School, Brown University, Providence, RI, USA |
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| Abstract: | Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle‐stimulating hormone (FSH), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle‐stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo. The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as a result, Ca2+ influx is stimulated, cAMP‐response‐element‐binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of FSH receptor‐mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females. |
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| Keywords: | ageing ca2+ endocrinology mouse models signal transduction signalling |
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