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On the mechanism of radiosensitization by 5-bromouracil
Authors:G. Hotz
Affiliation:(1) Institut für Strahlenbiologie, Kernforschungszentrum Karlsruhe, Karlsruhe, Germany
Abstract:Summary Experimental evidence for the sensitization of broth-suspended phage phivX-174 and its single-stranded infectious DNA by incorporation of 5-bromouracil against ionizing radiation is given. No influence of phage protein or molecular DNA-structure on the amount of BU-damage has been observed. The absence of desensitization by radical-scavenging compounds like cystamine in single-stranded DNA is discussed. It is deduced from the experimental data that host-cell and/or phage depending reactivation processes are involved in sensitization and desensitization of BU-DNA.
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