Genetic laboratory practices related to testing of the GJB2 (Connexin-26) gene in the United States in 1999 and 2000 |
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Authors: | Kenneson Aileen Myers Melanie F Lubin Ira M Boyle Coleen |
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Affiliation: | Centers for Disease Control and Prevention, National Center on Birth Defects and Development Disabilities, Atlanta, GA 30341-3724, USA. akenneson@cdc.gov |
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Abstract: | Given the rapidly growing area of molecular genetic laboratory testing, we sought to assess changing issues over a 2-year period of time pertaining to the availability of testing for GJB2 mutations associated with non-syndromic hearing loss. Laboratory assessments carried out by telephone interviews with directors or other key personnel revealed variations among laboratories in informed consent practices, evaluation of test requests for appropriateness, and the reporting of results. From 1999 to 2000, referral patterns shifted as did sources for reimbursement, policies regarding evaluation of incoming test requests, and reporting procedures. We propose that these results reflect changes occurring as a result of a new test moving from the research to the clinical phase. |
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