Molecularly imprinted hydroxyapatite thin film for bilirubin recognition |
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Authors: | Yang Zhengpeng Zhang Chunjing |
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Institution: | Institute of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China. zhengpengyang@yahoo.com.cn |
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Abstract: | A novel piezoelectric sensor has been developed for bilirubin (BR) detection, based on the modification of molecularly imprinted hydroxyapatite (HAP) film onto a quartz crystal by molecular imprinting and surface sol-gel technique. The performance of the developed BR biosensor was evaluated and the results indicated that a sensitive BR biosensor could be fabricated. The obtained BR biosensor presents high-selectivity monitoring of BR, better reproducibility, shorter response time (37 min), wider linear range (0.05-80μM) and lower detection limit (0.01μM). The analytical application of the BR biosensor confirms the feasibility of BR detection in serum sample. |
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