Association of a nonsynonymous polymorphism in PER 1 with diurnal preference in Korean adults |
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| Authors: | Seong Jae Kim Se Yong Lee In Bum Suh |
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| Affiliation: | 1. Department of Psychiatry, Doeun Hospital, Jincheon, South Korea;2. Department of Psychiatry, Kangwon National University Hospital, Chunchon, South Korea;3. Department of Laboratory Medicine, Kangwon National University Hospital, Chunchon, South Korea |
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| Abstract: | No nonsynonymous single-nucleotide polymorphism (SNP) in PER1 has been reported with respect to diurnal preference. We aimed to determine whether a functional polymorphism in PER1 is involved in diurnal preference. Forty-seven morning-type (MT, age: 44.57 ± 12.33 years), 59 neither-type (NT, age: 35.20 ± 9.53 years), and 50 evening-type (ET, age: 28.96 ± 8.03 years) subjects were included in the final analysis. A synonymous (PER1 2485 C/T, rs2735611) and nonsynonymous (PER1 2495 G/T, rs138577469) polymorphism at 10-bp away from the PER1 2485 C/T were investigated as candidate SNPs. For the PER1 2485C/T SNP, no significant genotype distribution was observed among the three groups. For the PER1 2495G/T, the MT group showed significantly higher genotype distribution, T allele frequency, and proportion of T allele-positive subjects when compared to the combined group of NT and ET. Our findings suggest that a nonsynonymous polymorphism in PER1, which has only been found in Korean adults, is associated with morning preference. |
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| Keywords: | Diurnal preference PER 1 nonsynonymous SNP |
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