A natural anti-periodontitis agent,epimedokoreanin B,inhibits virulence activities of gingipains from Porphyromonas gingivalis |
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| Authors: | Toru Kariu Tsuyoshi Ikeda Keisuke Nakashima Jan Potempa Takahisa Imamura |
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| Institution: | 1. Department of Life Science, Shokei University, Kumamoto, Japan;2. Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan;3. Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland;4. Department of Oral Immunology and Infectious Disease, University of Louisville School of Dentistry, Louisville, KY, USA;5. Department of Molecular Pathology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan |
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| Abstract: | Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens. |
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| Keywords: | Porphyromonas gingivalis gingipains flavonoids epimedokoreanin B |
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