Anti-photoaging effect of skin cream manufactured with ziyuglycoside I isolated from Sanguisorba officinalis on ultraviolet B-induced hairless mice |
| |
| Authors: | Mi-Young Yun Eun-Young Bae Seung-Woong Lee Soon-Ho Yim |
| |
| Institution: | 1. Department of Beauty Science, Kwangju Women’s University, Gwangju, South Korea;2. Dr. Bae is "R&3. D center, Elohim company, Daejeon, South Korea;4. Immnoregulatory Materials Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup-si, South Korea;5. Department of Medicinal Herbs Industry, Dongshin University, Naju-si, South Korea |
| |
| Abstract: | In this study, skin cream containing ziyuglycoside I isolated from Sanguisorba officinalis was manufactured and examined the protective effects of the skin cream against UVB-induced hairless mice. UVB-induced hairless mice were topically treated with the skin cream once a day for 5 weeks. Application of the skin cream did not exhibit side effect on body growth showing normal body weight and food efficiency in the mice. The skin cream treatment also was inhibited mRNA expression of interleukin (IL)-1β, matrix metalloproteinase (MMP)-2, MMP-9, and MMP-2 protein expression in the mice. Furthermore, the skin cream treatment inhibits epidermal wrinkle formation, wrinkle depth, wrinkle thickness, and collagen degradation in UVB-induced hairless mice. Therefore, the skin cream was able to play a role in the attenuation of photoaging caused by UVB irradiation via downregulation of mRNA expression of inflammatory cytokine IL-1β, MMP-2, MMP-9, and suppression of MMP-2 proteins expression. |
| |
| Keywords: | Ziyuglycoside I photoaging wrinkle depth epidermal thickness collagen degradation |
|
|
