Protection against UVB-induced damages in human dermal fibroblasts: efficacy of tricin isolated from enzyme-treated Zizania latifolia extract |
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| Authors: | Se-Ho Park Seung-Su Lee Myun-Ho Bang Sung Kwan Jo Kwang-Hwan Jhee |
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| Affiliation: | 1. Institute of Natural Science, Keimyung University, Daegu, Korea;2. Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi, Korea;3. Skin Biotechnology Center, Kyung Hee University, Suwon, Korea;4. BTC Corporation Ltd., Sangnok-gu, Ansan, Korea;5. Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi, Korea |
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| Abstract: | This study was undertaken to determine the effects of enzyme-treated Zizania latifolia (ETZL) and of its major compound tricin on skin photo-aging and to investigate the mechanisms involved. It was found ETZL and tricin suppressed matrix metalloproteinase (MMP) production and increased type I-procollagen production in UVB-irradiated human dermal fibroblasts (HDFs). Furthermore, ETZL and tricin significantly up-regulated the expressions of the antioxidant enzymes HO-1 and SOD1, reduced UVB-induced reactive oxygen species (ROS) generation and mitogen-activated protein kinase (MAPK) induction by ROS and thereby attenuated activator protein-1 (AP-1) expression. In addition, ETZL and tricin both reduced the phosphorylations of IκBα and IKKα/ß and κB blocked the nuclear translocation of nuclear factor-κB (NF-κB) p65. These results show that ETZL have skin protective effects against UVB and suggest tricin as major efficacious material in ETZL protecting skin photoaging. |
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| Keywords: | MAPK/AP-1 MMPs NF-κB tricin Zizania latifoli |
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