| Abstract: | In experiments on five awake cats, we studied the effects of bemitil, a drug possessing psychostimulatory, antidepressive,
and actoprotector properties (peroral introduction, 50 mg/kg), on the activity of neurons of the aminergic cerebral systems.
Eleven noradrenergic (NA-ergic) neurons of the locus coeruleus (LC) and 11 serotonergic (ST-ergic) neurons of the nuclei raphe (NR) were examined. A control experimental series was carried out on 8 NA-ergic neurons of the LC and 8 ST-ergic neurons
of the NR. Bemitil was found to exert opposite effects on the impulse activity of NA-ergic and ST-ergic brainstem neurons;
it suppressed impulsation of LC neurons and increased the spiking frequency of NR neurons within certain time intervals after
its introduction. Analysis of EEG showed that bemitil decreased the spectral power of the delta and theta activities, which
was accompanied by behavioral relaxation.
Neirofiziologiya/Neurophysiology, Vol. 37, No. 3, pp. 235–243, May–June, 2005. |
