Superunstable alleles at the cut locus in Drosophila melanogaster |
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Authors: | T I Gerasimova |
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Institution: | (1) Institute of Molecular Genetics, USSR Academy of Sciences, Moscow, USSR |
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Abstract: | Summary This is a detailed study of the reversions of the ct
MR2
allele putatively carrying á mobile element (MR-transposon) in the cut locus. Stable, unstable and superunstable revertants have been identified. Besides, a series of multiple unstable visible and lethal ct mutations derived from the ct
MR2
allele have been obtained. They are shown to include supermutable alleles. The results suggest that the MR-transposon is connected with at least three functions: excision; change of orientation; and change of position within the cut locus, these functions being disturbed in different ways in different unstable ct
+ and ct alleles. In some cases the mutant transitions are somehow strongly stimulated leading to superinstability, reaching the rate of 0.5. |
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Keywords: | |
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